Resident Evil 5 Walkthrough

Go back through the same gate you came in and head back to the bridge. After  the cutscene, take the elevator at the south side of the bridge. Star killing  all majinis around you, then follow the corridor. Jump down the ladder until  you reach the small pool then climb up again the other ladder and reach the  lever on the small balcony. Pull it. Some majinis will come to attack you  while the big door opens. Hide behind the pillars while you shoot the majinis  across the gap. There’ll be lots of them and they’ll be heavily armed. When  you think its safe, cross the gap and kill the rest of them.

Before pulling the levers by the second gate, take your time to explore the  area and take all the items you can find, specially herbs and sprays since you  will need those very soon. When you’re equipped and ready for action, pull  the levers by the gate to open it. *CHECKPOINT* Turn around and take care of  these Reapers first. When you kill them, head to the gate and it shall open.  Yes, you’ll have to take down two Gatling gun majinis at the same time, not to  mention countless other majinis. This can be a little bit tough, specially if  you’re at a higher difficulty level. Move a lot and hit them just when you  have the chance. Don’t give the space to shoot you and you should be fine.  When they fall down, steal their Hangar keycards and then head to the door on  the south side. Rush along the corridor and enter the next door.

Boss # 010 – Wesker

You have to shut down all light sources first. Head to the southeast side of  the area and pull the lever, then head north and pull the other one. Now head  to the southwest part, turn the last one off then head north, break the glass  and take the R.P.G. Take some distance from Wesker and shoot a grenade. He  should hold it with his hand. Quickly, take a regular weapon and destroy the  grenade. He should be stunned for a few moments, now is your chance to  restrain him while your partner tries to inject the serum. You will fail the  first time, just reload the R.P.G. with another grenade (there’s one on the  northeast crate). As soon as you’re done, hit him again, destroy the grenade,  restrain and inject the serum. Sometimes Wesker will go near the jet and will  start throwing some rockets at you. It’s not hard to dodge those, just keep  running and you should be fine. Also, he will turn the lights back on, make  sure all of them are off when you are shooting the grenades.

There’ll be a few cutscenes loaded with QTEs, make sure you hit them. Break  all the crates, take all the items and then head up the hill

Boss # 011 – Uroboros Wesker

Star by running up the hill until you and your partner split. Sheva will tell  you to go to high ground. Jump across the gap and take the left path up. If  you’re Sheva, shoot the orange blister on his back, if you’re Chris, help her  by shooting him in the same spot as well. After some time, he’ll get angry at  Sheva and will go after her. With Chris, head down the slope, take the path  left until you reach a big boulder. You may also need to help Sheva by  shooting Wesker. If you’re Sheva, run along the path until you reunite with  Chris. Head back to that higher ground area and shoot him. *CHECKPOINT* All  you got, magnums, rifles, shotguns, you name it. Try to hit his orange  blister which will move from his back to his front. If you stay away from him  he quite can not hit you. As soon as he goes down, there’ll be one last QTE  where you have to press LT+RT. As soon as you hit it you reach the final  chapter end.